:root{
  --bg:#0f1420; --panel:#171e2e; --panel2:#1f2840; --line:#2b3550;
  --text:#e7ecf5; --muted:#9aa7c2; --accent:#5b8cff; --accent2:#7c5cff;
  --known:#3fb27f; --known-bg:rgba(63,178,127,.14);
  --novel:#e0a83b; --novel-bg:rgba(224,168,59,.14);
}
*{box-sizing:border-box}
body{margin:0;background:var(--bg);color:var(--text);
  font:15px/1.5 system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif}
.wrap{max-width:960px;margin:0 auto;padding:0 20px}
.sr-only{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0 0 0 0)}
a{color:var(--accent)}
.site-header{background:linear-gradient(160deg,#1a2236,#0f1420);
  border-bottom:1px solid var(--line);padding:34px 0 26px}
h1{margin:0 0 6px;font-size:26px}
.tagline{margin:0;color:var(--muted);max-width:640px}
.tagline em{color:var(--text);font-style:normal;font-weight:600}
.meta-line{margin:10px 0 0;color:var(--muted);font-size:13px}

.search-box{position:relative;margin:26px 0 10px}
#search{width:100%;padding:15px 18px;font-size:16px;border-radius:12px;
  background:var(--panel);border:1px solid var(--line);color:var(--text);outline:none}
#search:focus{border-color:var(--accent)}
.suggestions{list-style:none;margin:6px 0 0;padding:6px;position:absolute;z-index:20;
  width:100%;background:var(--panel2);border:1px solid var(--line);border-radius:12px;
  max-height:320px;overflow:auto;box-shadow:0 18px 40px rgba(0,0,0,.45)}
.suggestions li{padding:10px 12px;border-radius:8px;cursor:pointer;display:flex;
  justify-content:space-between;gap:12px;align-items:center}
.suggestions li.active,.suggestions li:hover{background:var(--panel)}
.suggestions .sid{color:var(--muted);font-size:12px;font-variant-numeric:tabular-nums}
.suggestions mark{background:transparent;color:var(--accent);font-weight:700}

.empty{padding:40px 0;color:var(--muted);text-align:center}
.empty .hint{display:block;margin-top:8px;font-size:13px;opacity:.8}
.examples{display:flex;flex-wrap:wrap;gap:8px;justify-content:center;margin-top:20px}
.examples button{background:var(--panel);border:1px solid var(--line);color:var(--text);
  padding:7px 13px;border-radius:20px;cursor:pointer;font-size:13px}
.examples button:hover{border-color:var(--accent)}

.drug-head{display:flex;justify-content:space-between;gap:20px;flex-wrap:wrap;
  align-items:flex-start;margin:8px 0 18px}
#drug-name{margin:0;font-size:23px}
.ext{font-size:13px}
.stat-cards{display:flex;gap:10px;flex-wrap:wrap}
.stat{background:var(--panel);border:1px solid var(--line);border-radius:10px;
  padding:8px 14px;text-align:center;min-width:78px}
.stat b{display:block;font-size:19px}
.stat span{font-size:11px;color:var(--muted);text-transform:uppercase;letter-spacing:.04em}
.stat.known b{color:var(--known)} .stat.novel b{color:var(--novel)}

.controls{display:flex;justify-content:space-between;gap:14px;flex-wrap:wrap;
  align-items:center;margin-bottom:12px}
.tabs{display:flex;gap:4px;background:var(--panel);padding:4px;border-radius:10px;border:1px solid var(--line)}
.tab{background:transparent;border:0;color:var(--muted);padding:8px 16px;border-radius:7px;cursor:pointer;font-size:14px}
.tab.active{background:var(--accent);color:#fff}
.filters{display:flex;gap:10px;align-items:center;flex-wrap:wrap}
.chips{display:flex;gap:4px}
.chip{background:var(--panel);border:1px solid var(--line);color:var(--muted);
  padding:7px 12px;border-radius:7px;cursor:pointer;font-size:13px}
.chip.active{color:var(--text);border-color:var(--accent)}
.table-filter{background:var(--panel);border:1px solid var(--line);color:var(--text);
  padding:8px 12px;border-radius:7px;outline:none;font-size:13px;width:140px}
.downloads{display:flex;gap:6px}
.dl{background:var(--panel2);border:1px solid var(--line);color:var(--text);
  padding:8px 11px;border-radius:7px;cursor:pointer;font-size:13px}
.dl:hover{border-color:var(--accent)}

.pred-table{width:100%;border-collapse:collapse;font-size:14px}
.pred-table th{text-align:left;color:var(--muted);font-weight:600;font-size:12px;
  text-transform:uppercase;letter-spacing:.04em;padding:8px 10px;border-bottom:1px solid var(--line)}
.pred-table td{padding:9px 10px;border-bottom:1px solid var(--panel2)}
.pred-table tr:hover td{background:var(--panel)}
.c-rank{width:38px;color:var(--muted)} .c-score{width:150px} .c-status{width:80px}
.tname{font-weight:600}
.tid a{font-size:12px;color:var(--muted)} .tid a:hover{color:var(--accent)}
.scorewrap{display:flex;align-items:center;gap:8px}
.bar{flex:1;height:7px;border-radius:5px;background:var(--panel2);overflow:hidden}
.bar>i{display:block;height:100%;background:linear-gradient(90deg,var(--accent),var(--accent2))}
.scoreval{font-variant-numeric:tabular-nums;color:var(--muted);font-size:12px;min-width:42px}
.badge{font-size:11px;padding:3px 9px;border-radius:20px;font-weight:700;text-transform:uppercase;letter-spacing:.03em}
.badge.known{color:var(--known);background:var(--known-bg)}
.badge.novel{color:var(--novel);background:var(--novel-bg)}
.no-rows{color:var(--muted);text-align:center;padding:24px}

/* entity-type chips */
.chip.drug,.chip.ind,.chip.prot{font-size:11px;padding:2px 8px;border-radius:20px;font-weight:700;
  text-transform:uppercase;letter-spacing:.03em;border:0;cursor:default;vertical-align:middle}
.chip.drug{color:#7fb2ff;background:rgba(91,140,255,.16)}
.chip.ind{color:#e08bd0;background:rgba(224,139,208,.16)}
.chip.prot{color:#6fd3c0;background:rgba(63,178,178,.16)}
.tagline .chip{margin:0 1px}
#type-chip{margin-bottom:6px;display:inline-block}
.suggestions .s-left{display:flex;align-items:center;gap:8px;min-width:0}
.suggestions .sname{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.examples button{display:inline-flex;align-items:center;gap:7px}

.site-footer{margin-top:50px;border-top:1px solid var(--line);padding:22px 0 40px;color:var(--muted);font-size:13px}
.site-footer .src{margin-top:6px;font-size:12px;opacity:.75}